Everglades National Park

Since you haven't been to the keys before, I suggest that after you go to Everglades National Park ... Shark Valley is pretty good for a 1/2 day view, then maybe hit Biscayne National Park for the other 1/2 day. Stay at any of the national chain motels in Homestead/Florida City for the night. Get an early start in the a.m. and start driving to Key West. As I mentioned before, it's a bit over 100 miles, so the distance isn't great, but traffic can be slow. There are lots of tourist things to see on the way to KW... just pick and choose some on your way down, and save a few for your way back. Some thoughts... ( MM is mile marker, that's how you get directions on US 1 in the Keys) for interesting art work by locals, check out Rain Barrel at mm 87, Robbies to check out the tarpon ( MM 77.5) is interesting, Pigeon Key to get some history on the overseas railroad (mm 47) Big Pine Key and the deer ( mm 30) , the old bat tower on Sugarloaf ( mm 17) .. then hang out in Key West for as long as you want or can. For a first timer, I suggest you take the touristy Conch Train... you'll get a good overview of Key West. For a place to stay, try Island City House.... it's in old town and is B&B with roomy accommodations for the price ( everything is pricey in KW). All kinds of cool things to do in KW, depends on your likes. PM me if you want specifics on activities or restaurants.