Ever since I-75 opened all the way, my Lansing relatives have been driving to Ocala, Brooksville, and Tampa without stopping. With 2 or 3 drivers it is one very long day. Naples is going to be another half day, so you might plan a stop.
Driving with just myself, I need an overnight stop. Going south, this might be as near as Chattanooga or somewhere beyond Atlanta, that depends on my timing to hit Atlanta at a less busy time. Going north, my overnight is usually somewhere in Kentucky. I.E. either direction, long first day, shorter second day.
You need to learn how to winterize, de-winterize. What's needed to protect the plumbing is a 20-40 minute job, at the most. I go through it several times a year, because my season extends into winter I and I will take the RV out for the warm spells or for trips to Texas, Gulf Coast or Florida.
Going to Florida from Michigan, you will be dewinterizing at your first stop in Florida (if you want to use the RV), winterizing again before heading home.
When we would take out TT from Detroit to Brooksville, we would not try to live in it on the way down, we pulled it dry (that was how we winterized in the '60s) and slept in a motel enroute. The point of not trying to camp enroute, besides the winter weather issue, was it would cost at least an hour setting up and breaking down, sleep vs travel, even if we didn't unhook from the car, and we were trying to maximizing driving time.
This was with a TT made for dry camping, no electricity needed to operate anything. A modern RV you will need electrical hookups, or extra battery power, to get heat. In a C you may have a generator, but I've never had the courage to run mine overnight while sleeping, because if CO seeps in through the many openings in a RV, it is possible for the initial low levels of the gas to put you in a deep enough sleep that the CO detector will not wake you up.
Tom Test
Itasca Spirit 29B