We use a Goosebox. Main reason, is we use the bed to haul water around in bladders when disconnected and need as much space as possible.
We do use safety chains, and they marginally increase hookup time.
There is a small learning curve to getting the ball right under the connection point - most of the time now, I can get it on the first try. Wasn't always so quick and easy. If my toolbox didn't block the view from the backup camera, it probably wouldn't have ever been an issue.
They allow more articulation than a fifth wheel hitch - which is both good and bad. You can easily make contact between the overhang and the bed rails if you aren't careful off-road, but can also use the increased articulation to get further out there. Just something to consider. Not likely to make much difference if you primarily go park to park or stay on pavement. I think that because they allow for more articulation, you are less likely to torque your frame, but as a final note on this, I'm not exactly comfortable with getting the trailer so off camber that this becomes important.
Fort Knox Locks makes a great lock that fits over the coupler. I'm not aware of any comparably secure pin locks, but I haven't looked in a while and they may be out there.
Another thing to note is that it's a bit more difficult to screw up the hitching process. If it's on the ball, it's on. No improperly closed jaws or high hitching. If you're careful and double check everything, probably not an issue one way or the other. I dropped a trailer once because someone started talking to me during the hitching process and I forgot to check that the jaws were actually locked. A little more difficult to have that happen on a ball - but I wouldn't use this alone as a reason to go this route.
I've had probably half a dozen fifth wheel hitches. They all tow a little differently. The difference between a cheap Curt and a TS BD3 is far bigger than the difference between a TS BD3 and a Goosebox - so to answer your towing different question, not really any more significant than the differences between other fifth wheel hitches and pinboxes.
2000 Country Coach Magna 40',
4380W solar, 22.8kWh LiFePO4@48V, 450AH AGM@12V
2020 Jeep Wrangler Unlimited Rubicon 2.0T, cloaked on 37x13.5s