i have had 2 blow outs on one toyhauler and then years later caught one tire before it blew. at every fill up i walk around and put my hands on the hub area and a visual inspec all of the tires.
i have a friend that had a 2 year run of blowing atleast one LT tire per trip. i considered that his fault, long story. because of that i carry 2 spares with my tandem axle toyhaulers. 3 toyhaulers back, after the two tires blew out 4 hrs apart. blew 1 hr into the trip and the 2nd 4 hrs down the road. 2nd one blew on I70 ( kansas ) west bound, in road construction where they had narrowed it down to 1 lane and still lots of traffic at midnight! the 2nd one did some damage and was very sketchy changing out on the shoulder in that traffic. luckily i had 2 spares for the trip.
after doing a lot of reading and calling 2 tire manufacturers, i realized that for myself, going a min of 20% over the required axle rating with a speed rating of L or M was the best option. that toyhauler came with 5200 lbs axles, D range (8ply) tires with a speed rating of J on 15" rims. swapped out to E's ( 10 ply) and a speed rating of L. as far as brand goes, when your 7 -16 hrs from home, you get what they stock! after spec'ing my st tries that way, i didn't have another issue for almost 11 years. the last one was on a 900 mile trip, apprx 300 mile of road construction combined, across 3 states, and 75 mph as often as possible on 5 year old tires. belt broke and tread started to roll over to the side wall. luckily i caught that while filling up.
i have owned 6 toyhaulers in the last 21 years. all but 2 manufacturers spec'd out tires that barely met the axle ratings. they do sell 12 ply ( load range F) st tires ( speed rating L & M ) for 15" rims. less common in this area but they are online and i carry 2 spares anyway. that brand was chinese and one i had never heard of. after six 14 hrs ( round trip) runs, at 75 mph as often as possible, in 1.5 years, they showed no noteable signs of wear. set them 10 psi under max cold rating for hot days and truly have no idea if that makes a difference or not.
current toyhauler, i spec'd with 14 ply sailun 235-85x16's speed range L and received 235-80x16 tires without notification. the smaller tire was not a huge deal, i was just trying to match the dia of my truck tires to keep them all spinning at the same rpm. toyhauler weighs 7200 lbs empty and i add 3500 lbs to it for a dune trip. 14 ply tires may sound like over kill but with 7k lb axles, they are just over the axle rating at 3638 lbs each.