I had a 43' Voltage toy hauler then bought the MS Atlanta. I have not weighed mine but, I can tell you it has at least 1000 lbs more pin weight and, pulls noticeably heavier.
I estimate pin weight over 4000 lbs, and, loaded weight 21000+.
With that said, the Air Ride hitch and axles along with the braking system make it much more pleasurable to pull than the last rig.
I am sure the F350 will handle it ok, but it is going to squat down pretty good. The Ram goes down 3-3.5" and it has much heavier rear springs than Ford.