We had an '88 Damon Escaper built on the Toyota C&C. that thing was definitely a conversation starter.
We traveled all over the western US including the Big Horn Mtns, Rockies, Yellowstone, Glacier, west coast, Canada. I only had issues on 2 roads-going up 14A from the west in the Big Horns and going up the Beartooth Highway from the west. On both of those roads I stopped for a couple of minutes because the temp gauge moved up a bit, never got hot but got warm.
I had the 22Re engine and loved it. The one thing to remember when driving a Toyota RV is to keep the rpm's up. If you don't have a tach, install one. Those engines are built to spin. We bought ours with 20,000 miles on it and sold it with almost 80,000 miles. We sold because the dash air and roof air didn't work and we wanted to travel a little faster.