We've always traveled with large dogs and through the years, we have found that our female dogs are a little better with travel than the males. A lot of people with the small dogs are afraid of a 100+ pound dog but that is their problem, not ours. Our dogs have always been well behaved and are great around children.
When I redid the furniture in this coach, and our past coaches, I removed the carpet and put in furniture with removable seat cushion fabric that is washed after every trip. We also have a central vac unit to deal with the shedding.
We buy poop bags online and always carry a supply to clean up.
Our current Great Pyrenees has logged close to 100,000 miles with us and we expect that she will continue to travel with us for several more years.