We fulltimed in a truck/tt combo. Now we fulltime in a mh/towed combo.
It is much easier in the mh. We also like it much better. It is faster, more convenient, and more relaxing.
We have a 33' mh. It is the perfect size and we can actually get into quite a few parks that large rigs and truck/5er combos can't get into (just look at length limits in CA parks). If the road/campground is limited to 35', we just unhook the jeep and go. There is no truck/5er combination that can do that.
Today, we decided to take a 'shortcut' back to camp. There is no way an F250 or larger could have made it between those rock walls and through the washes - too wide, too long. And too heavy for the deep sandy parts. You can't tow a jeep with a 5er or vice versa.
Would we ever go back to a truck and 5er/tt? Nope. Not unless we were parking it somewhere long term.
Do we want something larger like a 40' DP? Nope, unless we were going to slow down and spend more time inside rather than outside.
You really need to examine how and why you travel. For many people, a truck/5er is perfect. For others it isn't. But there is no right answer. My response, above, is because a mh is right for us and the way we travel right now.