If you aren't doings so already, try engaging tow/haul. It will still downshift, but the shift points are a little more appropriate for a heavy vehicle and it should hold in gear a little more reliably, both going up and down.
As others have said, though, the V10 needs to rev quite a bit, particularly for a truck engine, to generate power. If it didn't downshift and rev up it would be quite a dog on the hills. It's just the nature of the beast. Although it may sound like it's going to shred itself to pieces, the engine is quite capable of running at the higher rpm's for reasonably long times without trouble.
Some people here have put in four star tunes and reported good results; among other things, they can tinker with the shift points some.
(Another way to improve this would be to get a newer motorhome with the six speed transmission, which has somewhat closer and more evenly spaced gear ranges. I think there are also some aftermarket overdrive/gear splitter units available that should help a lot...for a price.)