Having drive BIG trucks for 30 years loaded or empty and having more than one flat on a dual wheel setup, here's what I found acceptable...loaded or empty...
You can drive a limited distance on a single PROPERLY INFLATED single tire on a dual tire setup at reduced speed. 45 mph with your emergency flashers on is acceptable, I did it plenty of times.
If it's a tube type tire, NO because the friction of the tube in the carcass will generate enough heat to set the flat on fire but if it's tubeless, no issue. It will tend to come off the rim bead on one side (either side) and roll along. It will get warm but not overly hot and the inflated tire will get hot carrying the load, which is why it's important to reduce your speed.
If the flat tire has a fixable puncture you can continue to run it after repair. If it's a sidewall failure or tread seperation, it's junk and will need replaced WITH ANOTHER TIRE OF SIMILAR BRAND AND INFLATED HEIGHT AND WIDTH. No exceptions on the preceeding comment. Reason is, if you replace the failed tire with another of different INFLATED dimensions, the original tire or the new tire if bigger in INFLATED diameter, will assume most of the load and prematurely fail.
2015 Backpack SS1500
1997 Ford 7.3 OBS 4x4 CC LB