Safe travels. Depends on what time of day you leave and what your personal preferences are. We leave eastern Long Island around 5:30 AM - 6:00 AM on a weekday and check traffic on Google Maps as we get into Delaware.
Then make a decision as to whether or not we're staying on 95 or taking 896, to 301 to I-95. That route takes you through Waldorf, Md where you will hit a stretch of traffic lights, is preferable if Baltimore and DC look like there's traffic or if a rush hour is approaching.
Usually stop somewhere in southern NC. RVacation campground in Selma is right off i_95 on the east side. Carolina Crossroads in Roanoke Rapids is nice also if looking for a campground.
Pecan Park on the north side of Jacksonville is easy on/off, reasonable with long, pullthru sites and 50 amp.
We arrive in Fla on day two, around dinner time after the one stop and either head to Tallahassee, spend a night or two in Jax visiting friends or arrive at Disney's Fort Wildernss around 8:30 PM that second day.
Safe travel and have fun!