There are significant differences between the Chevy/Ford MH-C and the Sprinter based MH-C. Determine what you need and make the choice.
Some of the floorplans are not available in both "groups." That drove us to the Sprinter.
If you need size or more towing capacity that will drive you to the Chevy/Ford MH-C. The Sprinter cannot compete in that spec.
If cost is an issue, the Sprinter will cost more. They hold their value well in the used market. There are a lot more good used Chevy/Ford products available at favorable prices.
The Sprinter drives much straighter in similar conditions, the Sprinter handles like an MB should. When its windy both types can be a handful.
The cockpit of the Sprinter is comfortable, plenty of foot room to get in and out. The seating position is great. The view is great. Our seats are MB and fit just right.
Somewhere right around an altitude of 7,000 feet the Sprinter has more torque than the NA Chevy/Ford. At 10k the NA engines are hard pressed to make 70% of their rated torque. That turbo in the Sprinter makes a huge difference at altitude and when in the mountains going up a pass, its really easy comfortable driving. No sluggish performance. I still generally stay in the right lane, but can slip into the middle lane when heading out of Denver and pass the strugglers, without holding up traffic in the middle lane.
My wife actually likes to and looks forward to driving the Sprinter, as does our daughter.
Like, I said in the beginning, there is a place for both types of rigs. To paraphrase Harry Callahan, "A man's got to know his limitations."
Good Luck.
Rick