That is not too many miles on the 7.3 diesel, oilfield service fleets around here operating the type usually traded at around 200,000 to 300,000 miles (which might be 3-5 years).
It depends really on how many more miles you plan to put on it. At 5000 miles a year you could be looking at another 10 years of service. 50,000 miles a year, maybe a couple more years. Even then, what is going to be wearing out will be drivetrain parts behind the engine, not the engine itself.
As others have noted, for a C motorhome with that many miles, you need to be looking at the condition of the house. But even there, a lot of time on the road is not necessarily an issue, some RV rental operations used to order C motorhomes constructed such that they could lift the house off a worn-out chassis (200,000 + miles for gassers) and drop it on a new one.