We full timed in a tt for seven months before switching to a class A. We chose the tt over a 5er because we did not want a bigger truck and we liked having our truck bed available. We went from a diesel truck to a gas MH.
Based on our experience and only our experience, a MH is much easier, even with a toad if you move frequently. If you stay put more - a week to a month, a 5er or tt is better.
With the tt/5er set up you, essentially, have to go from camp spot to camp spot where you can unhook your tow vehicle and then go out and see sites or whatever else you want to do. Yes, you can stop in places with large parking lots but you have to make sure everything you want is there as you *usually* can't drop your tt/5er and come back later.
With a motorhome/toad set up, you can unhook your toad in a parking lot and go site see, shop, whatever. You don't have to find a campground first to unhook.
Motorhomes are better set up for moving; tt/5ers are better set up for stopping. tt/5ers typically have more space for their length than MH. MH allow one to access everything while moving.
It really just depends on how you travel. We were really committed to keeping our truck and tt. The space was more than enough, the storage excellent, and we really loved our truck. But, once we got out on the road, we realized life would be much much easier with a MH.
2015 Jeep Willys Wrangler
2014 Fleetwood Bounder 33C
States camped: all but Hawaii
more than 1700 days on the road