We have a Weber Q-220 and love it. It's a bit heavy if you try carrying it with the cast-iron grill plate still inside. I didn't like the idea of a long flex hose with full tank pressure in it. I'd also heard that some folks have had problems with the sensitivity of a whole-rig sized regulator when only using small flow rates for the grill.
I didn't want to haul a big 20-lb tank either. I solved the issue by getting a "squatty" 10-lb tank that has the same base ring size as a 20-pounder. I got a "stabilizing base ring" at Camping World and bolted it to the floor of an outside stow-bin. The tank is a very snug fit and doesn't seem to need additional tie-downs.
The only snag with the Q-220 is that it's about 3/4" too tall to put in the stow-bins of our MH, so I have to take the lid off every time I put the grill away. Not a big deal, with the hinge pins it has. We will be getting the fold-up cart for it before our next trip as we found a couple of CG's that wouldn't allow grills on the picnic table.