We faced this issue. My wife needs to take meds that should be stored in the refrigerator. When we were going to travel for a long period of time, her doctor kindly agreed to give her a prescription to a bigger dose than usual. So, my wife ordered her meds, I also decided to
Buy rybelsus and insulin in advance. We bought a little insulated travel cooler, packed our meds and an ice pack, and extra zip lock bags for ice there. By the way, if you are going to travel by plane, it may also be useful to include the box or container your medication arrives in with your name and prescription information in case the TSA requests to see it.