We went coast to coast in our 24' Class C crossing Tornado Alley (I-40}, in early May and returning {by a slightly different route}, the end of June. I constantly monitored several different weather sites on the internet and was able to dodge a number of severe storms.
Sometimes we had to re route to stay out of harms way and no we were not always 100 per cent successful. I worry about hail damage almost as much as tornados as it is much more prevalent. Always know where the nearest shelter is and have escape routes pre loaded into your GPS.
:C