Back to the access with slides in, for me, I think the "it's no big deal"/"it's a deal breaker" choice has a lot to do with how you use the RV.
If you will be driving to a destination and staying there for a while, I think it's no big deal. Have a cooler with snacks in the TV, pull over in a big space to put out the slide and use the bathroom. Get to your destination, put out the slide and enjoy the extra counterspace.
If you will be doing a lot of overnighting, staying in public campgrounds, etc., then it is more likely to be an issue. You might not be able to open the slide when parking overnight at truck stops, some public campgrounds may have overgrown trees that prevent you from opening the slide, etc.
The bathroom access may be an issue if either of you have a weak bladder. It could be an issue with little kids who tend to ignore having to pee until it's a major emergency - and then, that 10-15 second delay could be disastrous. Do that a couple times each day while on the road and you very well could decide access is a deal breaker (I say that as having been the small kid with a small bladder - 2 to 3 stops on a 4 hour drive and an emergency every time).