I went from 245/70r17 to 285/70r17 on my 2011 RAM. This was with a 3.77 axle ratio. This was a substantial change in diameter so I had the dealer reprogram the speedometer. I must say the tires look much better on the truck than the old ones.
There was a noticeably reduction in rpm when cruising and it seems like I gained some mpg - I get about 19 MPG on long freeway drives. Around town mileage is about as bad as it was before. I seldom use all the power available from the engine anyway, so acceleration still feels very good. The weight I tow is well below the maximum for my truck so I can't say I've noticed any difference there.