Too funny - four out of six responses tell us what he meant, but does not speak to his comment.
From personal driving experience, without the engineering data. We went from a four speed tranny and 3:73RE to a six speed tranny and a 4:10 RE. Did not notice a significant difference in actual 'feel', and the power and mileage seemed very similar. I still got 15-17 mpg empty, and 12-14 hauling. Climbing hills hauling was the greatest 'feel different' as the 4s x 3:73 was less power, while the 6s x 4:10 pulls really well.
But the 6s x 4:10 was ten years newer, so advances in technology besides the gear ratio makes a difference too. If I had a choice, I'd go with the 6s x 4:10 again without a second thought.
I know, not the 6s vs 10s tranny, but still a change in gearing and a result from it.