In 85K miles I have only ever had 1 tank if fuel that was subpar, 14 mpg empty and the next tank was 17. Both the same day on the interstate with similar weather. I'd never hit 14 empty prior, and haven't since.
Cetane booster actually lowers the useable BTU's and thus economy. This has been proven on the dyno, and chemically.
About the only time Cetane booster is good is when the tank will primarily be used in cold weather at low load. I use it for elk hunting and the like, where I won't get above 20 for a few hundred miles and many hours. Engines are designed, timed, around the cetane from the pump and that's perfect nearly all of the time.
I won't buy additives with cetane boost for this reason.