Fellow 6.7 owners, In April, DW & I purchased a 2015 F250 with the 6.7 diesel. Gotta say I love how it tows our trailer. Goes down the road like it is not even back there. My question is about...
I tow with mine at least 95% or more when its on the road. I can go close to 4000 miles (give or take) before I have to add DEF. So as long as you're getting at least 3500-4000 miles before running low, my experience says you're OK. If you don't tow as often, you get even better distance out of a full tank. Maybe even close to double that I would think.