If you use only one block, I would use it on the inner tire to reduce the stress on the axle.
With the Ram, the TPMS is a display only, not a warning system. So if a tire goes down, it will not notify you. For this reason, I would not tie two tires together as I wouldn't want both to go flat. Not warning is a negative to the Ram, but it is also a blessing because you can lower the tire pressure when running empty for a softer ride without having a constant light on the dash.
I would run the same pressure. The crown of the road is in the middle. Each side from the middle out is flat, not counting the ruts in the road.