Personally, I would not (and don't) risk running the gen when going to bed. However, if you do, I've read that it's important to keep all windows closed tight to prevent fumes from entering the rv (you should probably research recommended practices). It makes no difference which way the exhaust is pointing, it matters which direction the wind is blowing.
The danger of carbon monoxide is how it accumulates in your blood and how long it takes to clear. Repeated exposure in a short period of time, continues to increase levels in your blood. None of us ever wants to discover where the tipping point is. Be careful!