My tow vehicle is a 2003 Ford V10 excursion with 158,000 miles. Four years ago I put the 6.0L tranny cooler in place of the stock cooler. Before the switch, my temps would routinely run 190-205 in 9...
The first things I would check would be water pump and belt, radiator, and the thermostat. I don't have specific knowledge of your V10 but I can tell you that flushing the block on my 6.0 was worthwhile. Lots of treasures in those passages.