I'm runnign 50 lbs on my reg cab 2500 all around, except when loaded. My old SW CC K3500, with 265 16 rubber, I was 50-55 for the front, ie a diesel vs a 350 SB V8..... another 800 lbs on the fa. REAR was 45 or so when empty. Found no difference in ride quality with the 265's towing or other wise with D tires vs E, other than 3000 lbs of tire vs 3400. THe 265's in a D range were 40 lbs less than a LR E 245-16. With 7.5" rims, I found the D rated 265;s to handle loads better than the 245's, both of these handled loads better than an LRE 235-85 16. The width seems to be the key.
Marty