I drive the majority of the time. We have little ones so we try to keep the mileage between 200 and 300 miles per day so everyone can stretch their legs for extended periods at rest stops. I'm new to towing and so is my wife, but so far so good. I drive most of the time but have her do a bit too when the roads are smooth and empty.
I hitch up but have her help so we can both double check stuff when it comes time to hit the road. I usually set up the outside (chairs, play pen, stabilizers, unhitching) and she gets the interior ready. We both try to play separate roles as it helps get camp set up faster when little ones don't want to wait.