Best quickest route from Syracuse Ny to Pittsboro NC

Ok I see it now... is 220 a fast interstate road ?? I was looking at getting off 81 in Winchester andband taking 66 to 17 to 95 to 85 but you think 220 is better

I don’t see where 81 comes into 220?,I gotta brush up on my map skills

In North Carolina, US 220 and I-73 run together. Stay with I-73 to (north) I-85 to (south) US 421 to (east) US 64.

Tom

That's too easy. I-81 to US220