Best route between Columbus OH and Charleston WV

Thanks for the replies! Now I can feel comfortable choosing either one of them.

CampWinican

I've also driven between Columbus and Charleston many times over the years, with family in Ohio and all. I take US-33 all the way to I-77 at Ripley, WV, just north of Charleston. US-33 used to be horrible, but today it is nearly all 4-lane divided highway, with just enough 2 lane to keep you from falling asleep, mostly between Lancaster and Athens, Ohio, and to cross the Ohio river. In fact, we'll be making that trip both ways in a couple weeks to visit some of that family.

I've driven both, and would drive either one again. Now, I've driven US 23-US 35-I-64 the most, but this fall I'll probably go up I-77 to US 33 just for a change.