The Cherohala Skyway is a beautiful drive but so very similar to what you will be experiencing on the Blue Ridge Parkway. I would follow the parkway all the way to Charlottesville and get off to take in some wonderful attractions in Virginia. Drop off your 5th wheel at a campground and tour Thomas Jefferson's home near Charlottesville. Then pick up Route 29 toward Lynchburg and head south to Natural Bridge & Appomattox Court house. Virginia is a wonderful state for camping and historical sites. All the parks are well maintained.
Some of our favorite campgrounds are Meadows of Dan on the BRP & Hungry Mother State Park near Marion. Take your time in Virginia, there are many places to see!!