Depending on where you want to go on the coast from Valley of the Rogue US 199 is ok, but the last 10 miles or get quite crocked and slow but totally doable.
OR 42 is okay, OR 38 is good. OR 34, been years since I was on it it was a good logging road then, now I don't know.
OR 126 is good US 20 is very good. OR 22/18 is good. US 26/OR6 is good. US 26 is very good. US 30 is very good.
101 the length of the coast has some windy spots a few tunnels and some narrow roadway in spots but nothing that will give you any problems. No need to crowed the center line on any of the tunnels or bridges. The only way you will hit the wall is if you jump the curb.