Disneyworld to Ft. Meyers Beach

Agree with most. I-4 to I-75 is best for towing if you can miss rush hour in Tampa, Bradenton and Sarasota. I'd check the traffic maps before leaving as an accident can ruin the day. March is the worst month for traffic. Next route would be 27 to 29, to 80. US17 would have the most stop and go and a dozen towns. You could do 27 to 60 to 17 and miss the Winter Haven, Eagle Lake, and Lake Alfred lights.