Help getting from I-5 to Hwy 101 from Az to San Francisco

I recall that the 152 had some grade change but we were headed eastbound from 101 to the 5. The 41/46 should be OK. Keep in mind that the 101 is very curvy and may cause some car sickness but the scenery is incredible. And I wouldn't worry too much about the grad changes in your DP, it'll have plenty of power.