It would help to know your destination around San Francisco. Where are you staying? There are easy ways to get on 101 without going through the city, especially with a 40' MH and being your maiden voyage.
Napa Valley Expo is a great place to stay with a big rig. Then drive your car to the Larkspur ferry landing on the north side of the bay and take the short ferry across the bay to Fisherman's Landing in the city. From there you could pick up a small van tour of the city. It will return you to Fisherman's Landing, the ferry and your car. This is an excellent way to tour the city. Even our daughter who lives there was impressed with the tour. Here's a link:
Small Van Tour of San FranciscoAlso, are you going to continue up 101 from San Francisco?
