Hoboken NJ to Buffalo NY?

I would take I-80 West to I-81 North to Binghamton, NY. Take 17 West to I-390 North, then pick up 20A from near Mt Morris (sorry...don't remember the exit) west straight to Buffalo.

All 4 lane roads, except for 20A. If you don't want to take 2 lanes and go through some small towns, stay on I-390 to Henrietta, and pick up the NY State Thruway into Buffalo. Toll road though.

Have a safe trip!