I live in the area and have taken this stretch many times. You are going through the Pigeon river Gorge and trucks are limited to the right lane. Just get in behind a truck, keep a good following distance and use your tranny gearing to keep your speed down. It's an interstate so there are no hairpin turns or switchbacks but it is mostly down hill from Asheville and it has many curves and you will need to take it easy. Its not terrible. I have a 2500 gaser and I manage just fine.
Where in G'burg are you going for your stay? You can take exit 440, Wilton Springs, and connect to 321 to go into G'burg. You can take exit 435 if you want a Walmart to stop at before going to the campground. It leads to 321 also. Any other questions just ask.
