I have done the I-75 route from Detroit to Florida several times towing a 30' TT. Usually southbound in January and northbound in March. A couple of days ago I came back from Florida via 95/77/79/90 through Buffalo. Since I was not towing I wanted to see what the route was like. It was OK but seemed to be a lot more 2 lane rather than 3 lane and the elevations are a lot higher so I think there would be less chance of bad weather on 75.I will definitely go back to I-75 for towing after that trip.
Based on where you live I would be more concerned about blowing snow on the 400 (You will know where), the 401 between London and Chatham, and that open stretch of I-75 in Ohio. The biggest hill at Jellicoe Tennessee is only about 15 miles and is no steeper than climbing out of the Holland Marsh on the 400.
Just take a deep breath, relax, and watch the weather forecasts.
