We just came back from Crystal River, FL using that route the end of March. Very little construction going north until you get to Louisville. A second bridge over the Ohio River has just about been completed and we didn't have a problem going through there on a weekday about 6 p.m. The signage is a little confusing, but the bridges were fine.
Further north into Indiana has some one-lane construction zones, but again, it didn't really slow us down much. You can take I-69 north to Michigan that way and cross into Canada at Detroit or Port Huron or cut over toward Ohio at some point.