Illinois State Highway 54 North from Springfield

I was on that stretch of 54 just last weekend on my motorcycle. Traveled it many times pulling my 5er.
US 54 is a good road. You wont' have any problems with any kind of camper/trailer/rig outfit. It's a flat straight stretch of road. This time of year you will have farmers on the road on tractors pulling machinery going between fields so watch for slow moving vehicles. The only town of any size is Clinton. You'll go straight thru town so it's not a problem.
Warning tho there's not much along US 54 to see other than flat land and fields.