I worked on the east side of Louisville near the I 265 and 71 and would not recommend it at 5 o'clock. 265 is 2 lanes in each direction. My drive home in the direction you will be going, usually took over an hour compared to 35 minutes in the morning. That was just driving 10 miles on 265. I 65 is 3 to 5 lanes all the from Southern IN thru Louisville. Traffic does slow down but there are more lanes. If you want to avoid the toll, $7, I would go west and use 265, 64, 264 to 65. Cannot tell you what traffic is like because I seldom use those roads. I would stay on 65 straight.