Take the east bypass around Cinci...it's longer yes but worth the time to avoid the mess of traffic. I think I clocked it at 40 miles longer when I took it. I am one that prefers to get off the interstates and take U.S. highways instead. I enjoy the slower pace and we have many more options to stop and see things on the way. I always take U.S. 441 to FL.
All of your route choice would depend on where you intend to pick up 27.....right outside of Cinci or farther down?...and that is dependent upon your time frame...is this just a weeks getaway or are you snowbirding in FL? Remember too that most campgrounds won't have water on until you get to mid Georgia or farther.