Someone had recommended I take US27 to avoid Atlanta. Best I can see, that looks like a tough route. Atlanta is a B*, but I now have a much higher hatred of Cincy. Didn't help I got a late start ...
I have driven through Cinci many times and Atlanta a couple (neither recently). I find the best solution is to avoid rush hour traffic. Mid day is acceptable, just stick to the right.
If you really don't like traffic, get to major city BEFORE 6 AM. Drive straight through, do NOT take any bypass route.