Driven it through, but not in a motorhome: US-60 Charleston to connection with I-64. I know I could get my motorhome through there (big trucks used the route for almost 50 years) but would really rather not.
I've explored pieces of 60 east of that, some of it is more like motorcycle road than RV road. At one time or another I've driven most of US-60, in pieces, from Newport News to Fort Sumner. It comes through the middle of my town. As an alternative to the Interstates that replace it along the way, sometimes it is reasonable for travel, sometimes it is just nice for a leisurely drive. Western Virginia, it is leisurely scenic drive.
As a through route, you will be on I-64 to get through some of the places where there is room for only one road, and the Interstate replaced the old highway.