from Dallas to Amarillo on Rt 287
I make this route from Wichita Falls to Amarillo several times each year. In fact, will be doing so day after tomorrow. Nothing to worry about. The only adjustment I would make on this part of your route would be to avoid Dallas/Ft. Worth. Several good ways to get up from I-20 to US 82. One I will be using tomorrow will be US 69 from I-20 up to Bells, TX near Sherman. Then US 82 west to US 287.
I've also made the route from Mobile up to I-20 many times. There are several good possibilities--such as up to Hattisburg and on to Jackson. Well, I better leave others to fill in the details from Mobile to I-20. I'll stick to my comments about US 287.