When I travel I don't have a limited time schedule as I am retired. I can understand if you need to be at a certain place with time restrictions. You can opt to stay on I-65 and go through Birmingham but there is road construction at several interchanges and you may or may not encounter a delay. The road is rough in places and the rush hour traffic can be as bad as Atlanta at times.I can tell you that I-22 from Birmingham to Memphis is very good with minimal traffic.There is a new connector ramp off of I-65 onto I-22 that makes a smooth transition. There are truck stops along the way if you need fuel, food, rest, etc. I just like to travel the US highways when possible just to see America. Safe travels and enjoy the ride!