We have stayed at both and preferred James Island. It will be especially nice in November, as they will probably have their Christmas Light Display up. It is truly something spectacular to see! Their is so much to see in Charleston. We have only been there the one visit,so certainly missed a lot of sights. There is a very nice visitor center near downtown with all the information you would need. We purchased a two day plantation tour ticket for (I believe) 5 plantations-thinking it would be the best buy. It was difficult to see that many in the 2 days. Perhaps it would have been better to choose other plans. While in the general area, I would highly recommend Hunting Island State Park in Beaufort. It is only w/e, but right on the ocean. I absolutely loved it and the town of Beaufort! It is very busy in November, so highly suggest reservations. If you should decide you are interested in going there, I would be glad to suggest some sites for big rigs. Just send pm. Have fun!