A Lousiana native here and former NO resident, I will add a couple of comments. New Orleans is like every large city in that there are area's where casual visitors just should not go, particularly at night and especially late at night, remember nothing good happens after midnight. Now NO does have the disadvantage that one of those bad areas is close to it's major attraction, the French Quarter. My advice, which we follow on every visit, is do the French Quarter during the daytime and early evening, then head on back to the camper or elsewhere. Now if you are a partier and want to party late, stay in the main FQ area, avoid the fringes and take a cab back to wherever you are staying do not walk late an night especially if you are feeling "happy" after your party. BTW I have been given essentially the same warnings when I have stayed in Chicago, New York City, Indianapolis, well you get the message.
Now let me add that that are so many things to do and see in NO and the surronding area that in our visits the FQ is just a couple of hours of time, doing a little shopping in some of the unique shops in the Quarter, and the absolute requirement of Cafe Dumond for coffee and beignets. Also plan to have a least one meal at one of the great resturants in the Quarter but there are also many outside of there.
I would advise, and I hate when people say "just do a search", but I do have to say on this site there have been a great many comments about NO. Also contact the visitors bureau they will provide you with all the info you need for a great visit.
Have fun, allow more time, and oh yeah go on a diet before hand so you can enjoy the tremendous variety of great food in the area.