Jayco Eagle 281 rls - f250 towable?

You should be OK, but the real answer will come from the specification of your towing vehicle (TV). Before purchasing check out the Towing Guide and the actual weight rating on your TV.

This would be a good match for a late model 3/4 ton truck. Always check the payload rating before purchase against the pin weight of the trailer + cargo expected to be added.

Have been looking at 2006 Ford f250 sd xlt supercab short box 4wd

I believe it has these specs:

Curb Weight 6,207 lbs
Gross Vehicle Weight Rating 9,200 lbs
Max Payload 2,993 lbs
Max Tow: 8200

there should be 2 different tow ratings for the truck---one for conventional (bumper pull) & one for a 5th wheel

here's a link to a Ford towing guide on 06 models

https://www.fleet.ford.com/resources/ford/general/pdf/towingguides/2006RVguideApr08.pdf (maybe someone can make it a clicky)

Good on payload bad on max tow. But I think it may be more
Frank