Back from Minnesota - our trailer limped to the RV dealer (Ballantyne RV) in Victor, NY on 3 tires. We lost a wheel on the fifth wheel on the NYS Thruway. Did not feel a thing when it came off the RV....
When towing any of my trailers I always have a breaker bar with short extension and socket sitting on my rear (crew cab) floor to periodically check the lug nuts. Especially after a tire or wheel has been changed you need to re-tighten/test them every 100 miles or so for about 3 tests. Its a must on a trailer.---- If you had been checking frequently as I suggested you may have noticed the trouble brewing before it became a total failure.