Welcome to the 5'er family.
1- check and double check your hook up, do safety walk around before you start and at every stop.
2- drive slow while keeping up with traffic... 60mph is plenty fast for me
3- anticipate traffic ahead and keep a reasonable distance
4- make sure to adjust your mirrors, I like to be able to see my trailer tires when I turn, this way I know where I'm tracking.
5- be aware of your overhead clearance, most roads now have sufficient clearance but gas stations may not.
6- I set my Ford on tow mode and if road conditions allow on cruise control(some may not agree with cruise), relax, let the truck do it's job and don't rubber neck to much, your coach is following you...it is back there.
7- Some parking lot practice is always a good idea.
Most of all enjoy. GPG
PS: I like the center lane especially where the on ramps are short and busy, this avoids having to deal with jack rabbit drivers trying to out run you so they do not get behind a rig ... (my pet peeve)